| Pair Name | Gamma-Tocotrienol, Docetaxel | ||
| Phytochemical Name | Gamma-Tocotrienol (PubChem CID: 5282349 ) | ||
| Anticancer drug Name | Docetaxel (PubChem CID: 148124 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Gamma-Tocotrienol, Docetaxel | |||
| Disease Info | [ICD-11: 2B66.Z] | Oral cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | APAF1 | hsa317 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BIRC2 | hsa329 | |
| Down-regulation | Expression | BIRC3 | hsa330 | |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Activity | CASP8 | hsa841 | |
| Up-regulation | Activity | CASP9 | hsa842 | |
| Up-regulation | Expression | CYCS | hsa54205 | |
| Down-regulation | Expression | NFKB1 | hsa4790 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Down-regulation | Expression | RELA | hsa5970 | |
| Down-regulation | Expression | XIAP | hsa331 | |
| In Vitro Model | B88 | Metastatic human oral cancer cell | Homo sapiens (Human) | N.A. |
| Result | These findings suggest that the combination treatment with these agents may provide enhanced therapeutic response in oral cancer patients, while avoiding the toxicity associated with high-dose β-tubulin stabilization monotherapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | γ-tocotrienol enhances the chemosensitivity of human oral cancer cells to docetaxel through the downregulation of the expression of NF-κB-regulated anti-apoptotic gene products. Int J Oncol. 2013;42(1):75-82. doi:10.3892/ijo.2012.1692 through the downregulation of the expression of NF-κB-regulated anti-apoptotic gene products. Int J Oncol. 2013;42(1):75-82. doi:10.3892/ijo.2012.1692 | Click |
